Grailed is for high-quality, coveted items that can span across any genre. They are typically from well-known luxury designers and in wearable condition (Saint Laurent, Raf Simons, Rick Owens, etc).
Hype is for new streetwear releases and the latest drops (Supreme, Air Jordan, Yeezy).
Sartorial is for high-end classic menswear, ranging from clothing to footwear, from brands like Brunello Cucinelli, Tom Ford, and Alden.
Core is for well-known, mass market brands, as well as vintage clothing.